Addressing the selectivity and toxicity of antiviral nucleosides
Identifieur interne : 000A74 ( Main/Exploration ); précédent : 000A73; suivant : 000A75Addressing the selectivity and toxicity of antiviral nucleosides
Auteurs : Joy Y. FengSource :
- Antiviral Chemistry & Chemotherapy [ 0956-3202 ] ; 2018.
Descripteurs français
- KwdFr :
- MESH :
- pharmacologie : Antiviraux, Nucléosides.
- toxicité : Antiviraux, Nucléosides.
- Animaux, Humains, Structure moléculaire, Tests de toxicité, Virus.
English descriptors
- KwdEn :
- MESH :
- chemical , pharmacology : Antiviral Agents, Nucleosides.
- chemical , toxicity : Antiviral Agents, Nucleosides.
- drug effects : Viruses.
- Animals, Humans, Molecular Structure, Toxicity Tests.
Abstract
Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HCV, and influenza, and new drugs are being developed for the treatment of RSV, Ebola, coronavirus MERS, and other emerging viruses. However, this class of compounds has also experienced a high attrition rate in clinical trials due to toxicity. In this review, we discuss the utility of different biochemical and cell-based assays and provide recommendations for assessing toxicity liability before entering animal toxicity studies.
Url:
DOI: 10.1177/2040206618758524
PubMed: 29534607
PubMed Central: 5890540
Affiliations:
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Le document en format XML
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Feng</name></author></analytic><series><title level="j">Antiviral Chemistry & Chemotherapy</title><idno type="ISSN">0956-3202</idno><idno type="eISSN">2040-2066</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antiviral Agents (pharmacology)</term><term>Antiviral Agents (toxicity)</term><term>Humans</term><term>Molecular Structure</term><term>Nucleosides (pharmacology)</term><term>Nucleosides (toxicity)</term><term>Toxicity Tests</term><term>Viruses (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Antiviraux (pharmacologie)</term><term>Antiviraux (toxicité)</term><term>Humains</term><term>Nucléosides (pharmacologie)</term><term>Nucléosides (toxicité)</term><term>Structure moléculaire</term><term>Tests de toxicité</term><term>Virus ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Nucleosides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Antiviral Agents</term><term>Nucleosides</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Viruses</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Antiviraux</term><term>Nucléosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Molecular Structure</term><term>Toxicity Tests</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Structure moléculaire</term><term>Tests de toxicité</term><term>Virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Nucleoside and nucleotide analogs have played significant roles in antiviral therapies and are valued for their impressive potency and high barrier to resistance. They have been approved for treatment of herpes simplex virus-1, HIV, HBV, HCV, and influenza, and new drugs are being developed for the treatment of RSV, Ebola, coronavirus MERS, and other emerging viruses. However, this class of compounds has also experienced a high attrition rate in clinical trials due to toxicity. In this review, we discuss the utility of different biochemical and cell-based assays and provide recommendations for assessing toxicity liability before entering animal toxicity studies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Elion, Gb" uniqKey="Elion G">GB. Elion</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feng, Jy" uniqKey="Feng J">JY Feng</name></author><author><name sortKey="Furman, Pa" uniqKey="Furman P">PA. 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Boelsterli</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, D" uniqKey="Xu D">D Xu</name></author><author><name sortKey="Nishimura, T" uniqKey="Nishimura T">T Nishimura</name></author><author><name sortKey="Nishimura, S" uniqKey="Nishimura S">S Nishimura</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Feng, Joy Y" sort="Feng, Joy Y" uniqKey="Feng J" first="Joy Y" last="Feng">Joy Y. Feng</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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